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Medications for cerebral palsy

Children with cerebral palsy are often prescribed various medications to help them manage symptoms and live a normal life.

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How medications help

Cerebral palsy (CP) affects people differently and has varying levels of severity. Some children have little to no symptoms while others have significant developmental delays, change in muscle tone, and/or motor, speech, and cognitive issues. There are medications that can help those with CP control their symptoms and secondary medical issues, leading to a more manageable life.

There are medications to treat both primary and secondary issues stemming from cerebral palsy. For instance, medications are prescribed for children with incontinence caused by an inability to control the muscles used for urination.

Common medications used to treat cerebral palsy

Each child with cerebral palsy is likely to have a unique combination of medications to treat their specific condition. Some medications are short-term, while others are long-term. Medications and dosages are often used in combination and will likely be adjusted over time.

Common classes of medications for children with cerebral palsy include:

  • Anticholinergics (help reduce uncontrolled movements)
  • Anticonvulsants (control seizures)
  • Antidepressants (lessen symptoms of anxiety and depression)
  • Anti-inflammatories (for muscle pain)
  • Baclofen (reduce muscle tightness)
  • Benzodiazepines (reduce muscle spasms, reduce anxiety, and help prevent seizures)
  • Botox (helps to relax muscles; reduce muscle tightness)
  • Muscle relaxants (to reduce muscle rigidity/spasticity)
  • Nerve blocks (pain relief for chronic pain)
  • Stool Softeners

Medications for spasticity

Spasticity is a condition where certain muscles contract continuously and involuntarily. This is the most common movement problem in children with cerebral palsy.

Spastic cerebral palsy causes spasms and stiff muscles. This can be painful. Medications to control these symptoms may be given orally or through an injection. Some can be continuously infused through a small pump, similar to how Insulin can be given to diabetics.

Generalized spasticity is typically treated with muscle relaxants such as Baclofen or Botox and benzodiazepines such as Valium. Other medications can also be effective, and the health care team can help weigh the risks with the benefits

If spasticity is localized in a specific area, medication may be injected into those muscles. Botox is often used to reduce localized spasticity.

Common side effects from medications that reduce spasticity include:

  • Fatigue
  • Weakness
  • Loss of coordination
  • Dizziness
  • Headaches
  • Blurred vision
  • Nausea

There are also more serious short and long-term side effects and some medications are not recommended for children.

Medications for involuntary movement

Athetoid cerebral palsy (also known as dyskinetic cerebral palsy) is characterized by low muscle tone and involuntary movements. Children with dyskinetic CP may be prescribed medications to keep uncontrollable movements to a minimum.

Anticholinergic drugs ease symptoms by blocking nerve impulses that cause uncontrollable movements. They may also help control drooling, a common symptom of dyskinetic cerebral palsy.

Common side effects include:

  • Incontinence
  • Dry mouth
  • Dizziness
  • Constipation

Medications for seizures

Injuries to the brain increase the likelihood of developing seizures. Therefore, it isn’t surprising that many children with cerebral palsy develop some form of epilepsy. A report by the Centers for Disease Control in 2008 found that 41% of children with CP across multiple states had co-occurring epilepsy. There are several medications that reduce the frequency of seizures.

Two common medications used to treat seizures are barbiturates and benzodiazepines. Both slow the activity of the brain and nervous system, which helps prevent seizures. Phenobarbital is a common barbiturate medication given to newborns with seizure activity. Benzodiazepines that are often prescribed include Valium, Ativan, Dilantin, and Versed. These drugs are useful anticonvulsants, muscle relaxants, and anti-anxiety drugs.

Anticonvulsant medications, such as Keppra, are commonly used in children with CP to prevent seizure activity.

Some of the common side effects of these drugs include:

  • Dizziness
  • Weakness
  • Fatigue
  • Confusion
  • Low blood pressure
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Secondary conditions treated with medications

Secondary conditions are common in children with cerebral palsy and other birth injuries because of abnormal muscle movement and brain activity. Some examples of co-occurring conditions are acid reflux, constipation or incontinence, respiratory issues, and difficulty with feeding. Additionally, the brain damage that causes CP may also cause separate issues, such as intellectual disorders that require medication.


The inability to control urinary muscles often leads to incontinence, where you might leak urine or be unable to make it to a bathroom to urinate in time.

Tofranil is an antidepressant that can also be used to contract the bladder and neck muscles and control incontinence. DDAVP (desmopressin acetate) mimics natural hormones to decrease urine production and can be used as a nasal spray.

Acid reflux

A secondary issue caused by a lack of muscle control is gastroesophageal reflux. In children with CP, the muscle that prevents stomach acid from traveling up the esophagus may not be strong enough to prevent acid reflux. Over-the-counter medications that decrease acid production in the stomach, such as Zantac, are often beneficial.

Behavioral disorders

Some children with cerebral palsy develop behavioral or intellectual disorders. Attention deficit hyperactivity disorder (ADHD) and autism are common in children with CP. Adderall and Ritalin are some of the most common medications used to treat ADHD. Antipsychotic medications, such as Risperidone, are used to help with Autism symptoms.


Lactulose is a synthetic sugar used to treat constipation. MiraLAX is often used to treat children with constipation. It works by drawing water into the bowels to help soften stool and move it through the GI tract. This is considered to have low side effects.

Increased oral secretions

Children with CP often have limited or no motor control, which leads to excessive drooling. Anticholinergic medications, such as Rubinol, are effective in controlling the increased oral secretions.

Is medication necessary?

Many parents are understandably concerned about placing their children on medications. Fear of side effects and dependence on these medications often lead parents to explore alternatives.

Activities such as yoga, chiropractic care, music, aquatic therapy, acupuncture, occupational, and physical therapy can be effective in treating the symptoms related to CP and are often used in conjunction with medications.

Doctors and members of the care team can help decide what is best for your loved one. Please consult your child’s doctor before changing or discontinuing any medications. Doctors strive to tailor medications to each child’s specific needs. Discussing your goals and quality of life expectations with your child’s care providers can help your family find the best strategies to balance CP and its challenges.

To learn more about the various medications used to treat cerebral palsy, try downloading our free Cerebral Palsy Guide. This guide includes over 12 pages of in-depth information for children and parents of a child with CP.

Reviewed by:Katie Lavender, RN

Registered Nurse

  • Fact-Checked
  • Editor

Katie Lavender has over 8 years of experience as a Registered Nurse in postpartum mother/baby care. With hands-on experience in Labor and Delivery and a role as a Community Educator for newborn care, Katie is a staunch advocate for patient rights and education. As a Medical Reviewer, she is committed to ensuring accurate and trustworthy patient information.

Cerebral Palsy Guide was founded upon the goal of educating families about cerebral palsy, raising awareness, and providing support for children, parents, and caregivers affected by the condition. Our easy-to-use website offers simple, straightforward information that provides families with medical and legal solutions. We are devoted to helping parents and children access the tools they need to live a life full of happiness

  1. Mayo Clinic. (n.d.). Cerebral palsy: Diagnosis and treatment. Retrieved July 8, 2024, from https://www.mayoclinic.org/diseases-conditions/cerebral-palsy/diagnosis-treatment/drc-20354005
  2. National Institute of Child Health and Human Development. (n.d.). Cerebral palsy: Treatments. Retrieved July 8, 2024, from https://www.nichd.nih.gov/health/topics/cerebral-palsy/conditioninfo/treatments
  3. National Institute of Neurological Disorders and Stroke. (n.d.). Cerebral palsy. Retrieved July 8, 2024, from https://www.ninds.nih.gov/health-information/disorders/cerebral-palsy